The Institute of Medicine (IOM) updated their definition of clinical practice guidelines and addressed many limitations healthcare professionals faced (Tetreault, 2019). Prior to this update, practice guidelines were not upheld to any particular standard and: 

• were not required to disclose conflicts of interest
• were not transparent about the process used to create a recommendation
• did not have a clear, working relationship with systematic review committees
• did not necessarily disclose bias of recommendations concerning funding sources
• were not comprised of interdisciplinary professionals 

The IOM's Clinical Guidelines We Can Trust addresses all of these points and standardizes the quality of practice guidelines that make it to publication. Still, there are certain limitations that prevail, including (but not limited to) a lack of:

• systematic reviews or meta-analyses on specific clinical situations, therapies, or devices
• well-developed and thorough studies on rare clinical situations or effects on individuals from marginalized and/or underserved communities